2018 Bioapplications of acoustic crystals, a review

Authors: Munawar Hussaina, Frank Ruppb, Hans P. Wendela,Frank K.Gehringc

Journal: TrAC Trends in Analytical Chemistry Volume 102, May 2018, Pages 194-209,doi.org/10.1016/j.trac.2018.02.009


a  Biosensor Research Group, Thoracic, Cardiac and Vascular Surgery Department, Tuebingen University, Germany

b  Section Medical Materials Science & Technology, University Hospital Tuebingen, Tuebingen, Germany

c  Former Institute of Clinical and Experimental Transfusion Medicine and Centre of Clinical Transfusion Medicine (IKET) and ZKT, BW/H, Tuebingen University, Germany


The acoustic crystal innovation is picking up fame as an emerging equipment for “Point of Care” (POC) applications in biological part of clinics, while the unprecedented capability of the technology is not perceived yet. The acoustic equipment is attractive due to its detecting properties of ultra-sensitivity and selectivity, reproducibility and repeatability, precision and constancy. The first part of the review article highlights the “clinical overlapped biological areas” especially focusing on proteins and cells, macro-molecules and supra-molecules, drugs and chiral sensing, bio-markers and immuno-sensors, and “acoustic bio-electronics” including an overview of the worldwide crystal market. The technology status has been featured by utilizing the approach of “reviewing the reviews” for providing an overview of the “world of the acoustic bio-applications”. The second principle part of the article solidly concentrates the acoustic investigations on haemostasis via reviewing the key literature from 2010 to January 2018.