2023 Biomacromolecular Characterizations Using State-of-the-Art Quartz Crystal Microbalance with Dissipation

Authors:
Jingjing Wei*, Yu Shao, Shixin Qiao, Shaogang Hou, and Wen-Bin Zhang*

Journal:
Journal:  Anal. Chem. 2023, 95, 45, 16435–16446,doi.org/10.1021/acs.analchem.3c02499

Institute:

College of Chemical and Environmental Engineering, Anyang Institute of Technology, Anyang, Henan 455000, China
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry & Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China
Pharmaceutical Technology, Institute of Pharmacy, Faculty of Medicine, Leipzig University, 04317, Leipzig, Germany
Interdisciplinary Center of Material Science, Martin Luther University Halle-Wittenberg, D-06099, Halle (Saale), Germany

Abstract:

Biomolecular characterization is essential in fields such as drug discovery, glycomics, and cell biology. This feature article focuses on the experimental use of quartz crystal microbalance with dissipation (QCM-D) as a powerful analytical technique to probe biological events ranging from biomacromolecular interactions and conformational changes of biomacromolecules to surface immobilization of biomacromolecules and cell morphological changes.